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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP2A All Species: 23.33
Human Site: T1157 Identified Species: 36.67
UniProt: P11388 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.29
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P11388 NP_001058.2 1531 174385 T1157 E K E Q E L D T L K R K S P S
Chimpanzee Pan troglodytes XP_516332 1634 184611 D1183 A K G R E V N D L K R K S P S
Rhesus Macaque Macaca mulatta XP_001092092 1620 182490 D1169 A K G R E V N D L K R K S P S
Dog Lupus familis XP_537646 1532 174610 T1157 E K E Q E L E T L K R K S P T
Cat Felis silvestris
Mouse Mus musculus Q01320 1528 172859 T1154 E K E Q E L N T L K Q K S P S
Rat Rattus norvegicus P41516 1526 173202 T1154 E K E Q E L N T L K K K T P S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519680 1746 195650 T1185 N K T Q E L E T L K R K S P A
Chicken Gallus gallus O42130 1553 174974 D1149 N K D K E L E D L K H K S P S
Frog Xenopus laevis NP_001082502 1579 178601 D1147 T K N T E L Q D L K R K S P T
Zebra Danio Brachydanio rerio NP_001003834 1574 177254 T1153 A K M T E L N T L K M K A P A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15348 1447 164377 K1106 S S K A K K E K E V D P E K A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23670 1520 172316 T1168 S A A K A V E T K L S D Y D Y
Sea Urchin Strong. purpuratus XP_783546 1448 163750 S1106 S M I S Q L T S R G Y D S D P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30182 1473 164089 A1122 S E Y D Y L L A M A I A S L T
Baker's Yeast Sacchar. cerevisiae P06786 1428 164196 D1088 D V K G A T S D E E D E E S S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 67.2 67.5 93.6 N.A. 89 88.7 N.A. 71.3 76.3 70.7 67.9 N.A. 51.2 N.A. 53 58.9
Protein Similarity: 100 78.6 78.4 96.4 N.A. 93.6 93.2 N.A. 79.1 85 81.8 78.8 N.A. 66.8 N.A. 70.4 73.4
P-Site Identity: 100 60 60 86.6 N.A. 86.6 80 N.A. 73.3 60 60 53.3 N.A. 0 N.A. 6.6 13.3
P-Site Similarity: 100 80 80 100 N.A. 100 100 N.A. 86.6 80 66.6 73.3 N.A. 26.6 N.A. 26.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. 45 42.2 N.A.
Protein Similarity: N.A. N.A. N.A. 61.4 60.4 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 20 7 7 7 14 0 0 7 0 7 0 7 7 0 20 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 7 7 0 0 7 34 0 0 14 14 0 14 0 % D
% Glu: 27 7 27 0 67 0 34 0 14 7 0 7 14 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 14 7 0 0 0 0 0 7 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % H
% Ile: 0 0 7 0 0 0 0 0 0 0 7 0 0 0 0 % I
% Lys: 0 67 14 14 7 7 0 7 7 67 7 67 0 7 0 % K
% Leu: 0 0 0 0 0 67 7 0 67 7 0 0 0 7 0 % L
% Met: 0 7 7 0 0 0 0 0 7 0 7 0 0 0 0 % M
% Asn: 14 0 7 0 0 0 34 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 7 0 67 7 % P
% Gln: 0 0 0 34 7 0 7 0 0 0 7 0 0 0 0 % Q
% Arg: 0 0 0 14 0 0 0 0 7 0 40 0 0 0 0 % R
% Ser: 27 7 0 7 0 0 7 7 0 0 7 0 67 7 47 % S
% Thr: 7 0 7 14 0 7 7 47 0 0 0 0 7 0 20 % T
% Val: 0 7 0 0 0 20 0 0 0 7 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 0 7 0 0 0 0 0 7 0 7 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _